Zhu et al. showed that deoxycholic acid could promote proliferation and invasiveness of CRC cells (Zhu et al., 2012).On the other hand, a study by zhang et al. demonstrated that ursodeoxycholic acid could inhibit the malignant progression of CRC through the TGR5-YAP axis (Zhang et al., 2021). The gene discussed is GPBAR1; the disease is colorectal carcinoma.