These data suggest that mutated PCDH19 contributes to disease phenotype through mechanisms other than cellular interference in mosaic condition, and this is in agreement with clinical studies which have identified human males with ASD (autism spectrum disorder) carrying variants in PCDH19 gene (Piton et al., 2011; van Harssel et al., 2013; Chouery et al., 2023). This evidence concerns the gene PCDH19 and autism spectrum disorder.