tmao, scfas, bile-acid, blood-pressure, c-reactive protein, cardiovascular disease, coronary artery disease, coronary heart disease, diabetes, diet, dysbiosis, gut microbiota, heart failure, hypertension, insulin-resistance, mediterranean diet, metabolic syndrome, metabolite, metabolomics, microbiota, myocardial infarction, nutrition, obesity, risk factors. This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.