The main keywords were categorized into 10 major clusters: “#0 NLRP3 inflammasome activation,” “#1 gut-brain axis,” “#2 short-chain fatty acids,” “#3 caspase-1,” “#4 expression,” “#5 ulcerative colitis,” “#6 gut microbiota,” “#7 gasdermind,” “#8 inflammatory bowel disease,” and “#9 colitis.” The dots appearing on each timeline represented the high-frequency keyword nodes appearing in that cluster. The gene discussed is CASP1; the disease is colitis.