Allobaculum produces trimethylamine oxide (TMAO) (Zhu et al., 2016), which may promote fat production by inhibiting bile acid-mediated hepatic farnesoid X receptor signaling, inducing IR, thereby affecting blood glucose homeostasis and promoting the development of T2DM (Chen et al., 2022). This evidence concerns the gene NR1H4 and type 2 diabetes mellitus.