Additionally, chronic swimming exercise (30 min per day, 5 times per week) (Liu et al., 2015; Bai et al., 2021) and voluntary wheel exercise (averaging 8–12 km per night) (Lee et al., 2018; Zhang et al., 2019) also inhibited the NLRP3 inflammasome overactivation due to depression, high-fat diet, and chronic kidney disease. This evidence concerns the gene NLRP3 and major depressive disorder.