NLRP3 and inflammatory bowel disease: However, excessive inflammation from abnormal NLRP3 inflammasome activation is closely associated with the development of inflammatory diseases such as atherosclerosis (AS), type 2 diabetes mellitus (T2DM), inflammatory bowel disease (IBD), and neurodegenerative diseases (Toldo et al., 2022; Sharma and Kanneganti, 2021; Yao J. et al., 2023).