MFN2 and cardiac hypertrophy: A study found that 8 weeks of treadmill exercise reduced mitochondrial fusion protein (mitofusin 2, MFN2) expression in the hearts of hypertrophic mice and suppressed the downstream NLRP3/caspase-1/IL-1β signaling pathway, thereby alleviating myocardial hypertrophy and improving cardiac function (Ma et al., 2021).