TMEM175 and Parkinson disease: While hTMEM175 is highly expressed in dopaminergic neurons in the dense part of the nigra and microglia in the cerebral cortex, the progression of PD may be driven by a vicious cycle between dying neurons and microglia through oxidative stress, mitochondrial autophagy, and autophagy dysfunction, α‐synuclein accumulation, and pro‐inflammatory cytokine release [64, 65, 66].