Other grade 3 treatment-related toxicities included proteinuria (n = 2; 5%), elevated aspartate aminotransferase (n = 2; 5%), headache, diarrhea, elevated alanine aminotransferase, hyponatremia, hypokalemia, dyspnea, and syncope (each n = 1; 2%). This evidence concerns the gene GPT and Hypokalemia.