IRS1 and hepatocellular carcinoma: For example, PUS1 boosts the translation capacity of several oncogenic mRNAs, such as insulin receptor substrate 1 (IRS1), serine hydroxymethyltransferase 2 (SHMT2), MDM2 and c‐MYC, in a pseudouridylation‐dependent manner, thereby promoting tumourigenesis in hepatocellular carcinoma (HCC).54