In myelodysplastic syndrome, PUS7‐mediated pseudouridylation of mTOG promotes a direct Ψ‐dependent interaction with PABPC1, disrupting the recruitment of the translational co‐activator PABPC1‐interacting protein 1 (PAIP1)44, 45 significantly hindering the translation of transcripts with pyrimidine‐rich sequences (PES) in the 5′‐UTR, such as 5′ terminal oligopyrimidine (TOP) tracts, which encode components of the protein synthesis machinery and are frequently remodelled in tumours.46 This evidence concerns the gene PUS7 and neoplasm.