Also, we showed that CA can impact the cell viability of the GBM cells with p53 mutation (U251 cell line) as well as H4 cell line which are LGG cells [28]; but the elucidation of the molecular mechanism of action of CA on both the brain tumors GBM and LGG is essential to evaluate the cell entities and cell pathways affected. This evidence concerns the gene TP53 and glioblastoma.