The loss of E-cadherin induced by Hakai, upon phosphorylation by the protein kinase Src, leads to its endocytosis, disrupting cell‒cell contacts and, subsequently, inducing the epithelial-to-mesenchymal (EMT) transition process, a critical process involved in cell invasion, tumor progression, and metastasis [16, 17]. The gene discussed is CBLL1; the disease is neoplasm.