Later, the alkaloid daurisoline, derived from the plant Menispermum dauricum, was shown to target Hsp90, resulting in an increased degradation of Hakai and decreased ubiquitination and degradation of E-cadherin, both in vitro and in vivo, with important implications for tumor growth, EMT markers, and angiogenesis [50]. The gene discussed is CDH1; the disease is neoplasm.