ESR2 and obesity due to melanocortin 4 receptor deficiency: Correlations between ARO, ESR1, ESR2, and ESR1:ESR2 gene expression in SAT with markers of obesity and insulin resistance, sex hormones, and ex vivo glucose uptake (Table 2 and Fig. 4) were performed in the combined cohorts 1 and 2, including individuals with or without obesity and T2D, to ensure comprehensive coverage across a wide range of obesity and insulin resistance.