ARO gene expression correlated positively with age, markers of obesity (eg, BMI, waist-hip ratio [WHR; see Fig. 4A], body fat percentage), and markers of hyperglycemia and insulin resistance (eg, HbA1c, homeostatic model assessment of insulin resistance [HOMA-IR] (Fig. 4B), fasting insulin) (P < .05). Here, CYP19A1 is linked to obesity due to melanocortin 4 receptor deficiency.