In light of this finding, a small percentage (15.8%) of HER2 + patients in this cohort could have contributed to the significant univariate association, while a large percentage (76.7%) of ER + patients and perhaps differences in HER2 + vs HER2− tumour microenvironments could contribute the insignificant multivariate association between HER2 status and NLR. This evidence concerns the gene ERBB2 and neoplasm.