PFK1 is generally highly active in cancer cells due to allosteric activation8, but modulation of its activity, for example by the TP53-induced glycolysis and apoptosis regulator (TIGAR)9 or the 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4)10 can also promote cancer cell viability by supporting flux into the PPP. The gene discussed is PFKFB4; the disease is cancer.