BRAT1 and glioblastoma: Additionally, proteomic data obtained from the GSC line NCH644 suggests a regulatory role of BRAT1 on stemness properties of GBM with markers being decreased in BRAT1 KD cells (ALDH1, PROM1), as well as its connection to the DDR through ATM and ATR kinases, potentially further contributing to modulation of stemness [76] and radiotherapy resistance [45, 46, 77, 78].