Signaling pathways such as the mitogen-activated protein kinase (MAPK)/ extracellular signal-regulated kinase (ERK), phosphoinositide-3-kinase (PI3K)/ Akt/ mechanistic target of rapamycin (mTOR), and wingless/integrated (Wnt) play critical roles in regulating cytoskeletal dynamics, cell adhesion, and extracellular matrix remodelling, thereby promoting GBM cell migration and invasion [10]. This evidence concerns the gene MTOR and glioblastoma.