CDK5 and cancer: Overall, the obtained phosphoproteomic data from both cell lines suggests BRAT1-dependent regulation of either migration-associated kinases like MAPK3, MAPK8, BRAF and PKD3, or regulators of cytoskeletal dynamics and cancer cell migration/invasion, such as CDK5 [24, 40–43, 53–56, 79, 80] or even modulating Wnt signaling via TNIK [51, 52].