BIRC2 and esophageal squamous cell carcinoma: Gene colocalization analysis was performed, showing two prognostic model genes (ATP6V0E1 and BIRC2) in Fig. 9B, C. MR analysis found that gastro-oesophageal reflux were not significantly associated with ESCC based on SNP of TIIC-RNA gene, but rs148710154 and rs75146099 SNP sites had a significant correlation between them (the result of a single SNP can be seen in gastro-oesophageal reflux_to_cancer_MR_snps_result.xlsx file, Fig. 9D-F).