CTNNB1 and Intellectual disability: The first report linking Ctnnb1 mutations to intellectual disability (ID) was published in 2012 (de Ligt et al. 2012), followed by the identification of de novo mutations associated with a recognizable syndrome featuring autistic traits in 2014 (Dubruc et al. 2014; Kuechler et al. 2015), whereas the syndrome was first identified in a study by Tucci et al. who showed an impact of β-catenin mutations on neurodevelopmental features in a mouse model which correlated with patient phenotypes (Tucci et al. 2014).