Knockdown of cysteinyl-tRNA synthetase (CARS) inhibits ferroptosis induced by erastin, whereas overexpression of CARS enhances the sensitivity of several cancer cells to erastin.[24] Overexpression of HSPB1 was also found to inhibit erastin-induced ferroptosis.[25] Furthermore, the knockdown of the lysosomal protein prosaposin mediates neuronal ferroptosis by triggering lipofuscin formation.[26]. The gene discussed is CARS1; the disease is cancer.