PRRT2 and Parkinson disease: In addition, stress stimulates the release of corticosteroids, activates the protein kinase C (PKC) pathway, and induces the interaction of 15-LOX with phosphatidylethanolamine binding protein 1 (PEBP1), resulting in the formation of 15-HpETE-PE complex, which promotes PD progression by triggering plasma membrane phospholipid peroxidation leading to ferroptosis in dopaminergic neurons.[41] Ca2+-independent phospholipase A2β (iPLA2β) has been found to act as an important regulator of ferroptosis, allowing cells to avoid ferroptosis by hydrolyzing the 15-HpETE-PE complex.