Specifically, GPX8 was markedly overexpressed in BRCA, COAD, ESCA, GBM, HNSC, KIRC, KIRP, LIHC, LUAD, LUSC, and STAD tumor tissues compared with normal tissues, while it was downregulated in KICH, PRAD, THCA, and UCEC tumor tissues (P < .01). This evidence concerns the gene GPX8 and neoplasm.