Specifically, GPX8 was markedly overexpressed in BRCA, COAD, ESCA, GBM, HNSC, KIRC, KIRP, LIHC, LUAD, LUSC, and STAD tumor tissues compared with normal tissues, while it was downregulated in KICH, PRAD, THCA, and UCEC tumor tissues (P < .01). The gene discussed is GPX8; the disease is gastric adenocarcinoma.