Insomnia has been linked to metabolic disruptions and elevated electroencephalogram activity during Non-Rapid Eye Movement sleep.[4,5] These include elevated systemic metabolic rate during sleep and wakefulness, elevated cortisol and adrenocorticotropic hormone early in sleep, and reduced levels of pentraxytryptophan and gamma aminobutyric acid during insomnia. The gene discussed is POMC; the disease is insomnia.