In states of insomnia, levels of inflammatory factors such as tumor necrosis factor-α are typically elevated, and SOCS3 helps alleviate inflammation by inhibiting these signaling pathways.[53] Whereas other studies have shown that decreased SOCS3 expression induced apoptosis,[54] SOCS3 overexpression reduced apoptosis.[55] By regulating the expression of SOCS3, it may be possible to improve the inflammatory and apoptosis state associated with insomnia, leading to positive clinical outcomes. Here, TNF is linked to insomnia measurement.