SOCS3 and insomnia: GO analysis showed that apoptosis in insomnia was mainly related to “immune response,” “T cell differentiation in thymus,” and “positive regulation of MAPK cascade.” Western Blot and qRT-PCR experiments showed that BCL2, SOCS3, IL7R antiapoptotic indexes were under-expressed in modeled hippocampal neuronal cells compared to normal hippocampal neuronal cells.