LAMB2 and head and neck squamous cell carcinoma: Cytoplasmic laminin expression levels were elevated in poorly differentiated invasive oral squamous cell carcinoma.[14] A study aims to develop an in vitro 3D model that simulates intraoral HNSCC, with primary advantages including the ability of cancer cells to infiltrate the connective tissue matrix following the rupture of the BM.[15] The BM serves as a critical barrier against cancer cell invasion and significantly influences the survival prognosis of tumor patients.