There were small increases in the risk of IBC for those whose DCIS was detected by physical exam, for those with a cribriform DCIS architectural pattern, and for those with punctate necrosis (Table 2), and there were small decreases in risk for those who were ER-negative, PR-negative, or HER2 positive (Table 3). Here, ESR1 is linked to ductal breast carcinoma in situ.