In particular, there were strong positive associations with IBC risk in pre/perimenopausal women with punctate necrosis, in postmenopausal women whose DCIS was detected by physical exam, in those treated with BCS who had DCIS architectural patterns other than the main types, and in those who developed ipsilateral IBC and had involved DCIS margins, and there were inverse associations with HER2 positivity in those treated with BCS and with DCIS microcalcification in those who were treated by mastectomy. Here, ERBB2 is linked to ductal breast carcinoma in situ.