CHEK2 and hereditary neoplastic syndrome: Among the VUSs identified, many were in genes known to cause hereditary breast cancer, such as ATM, CDH1, CHEK2, PALB2, and RAD51D, in addition to BRCA1/2, as well as in genes responsible for other hereditary tumor syndromes, such as APC, MLH1, MSH3, and RET. Importantly, it should be noted with extreme caution that some of the VUS evaluations changed between the time of diagnosis and the present [22].