To systematically study the relationships between BCR repertoires in tumors and normal peripheral compartments, we performed RNA-based targeted BCR repertoire analysis from four tissue types: tumor (tum), corresponding normal tissue (norm), tumor-draining LNs, and peripheral blood mononuclear cells (PBMC), of 14 cancer patients (melanoma, n=6; lung cancer, n=4; and colorectal cancer, n=4). Here, BCR is linked to lung carcinoma.