Differences in other CDR-H3 properties, such as mean kf3 (b-sheet preference), kf4 (inversely correlated with hydrophobicity), predicted interaction strength, and charge between different tissues, including increased central-CDR-H3 charge in the tumor compared to normal tissue, may suggest a less mature and less specific BCR repertoire of tumor-infiltrating B-cells. The gene discussed is BCR; the disease is neoplasm.