Specifically, PROT‐a‐300 (C1QBP), PROT‐a‐2235 (PDK1), and PROT‐a‐2575 (MRMT3) demonstrated notable associations with ALS (IVW: OR = 1.0730, 95% CI 1.0210–1.1278, p = 0.0055; IVW: OR = 1.0584, 95% CI 1.0154–1.1032, p = 0.0073; IVW: OR = 1.0354, 95% CI 1.0078–1.0637, p = 0.0116). Here, PDK1 is linked to amyotrophic lateral sclerosis.