Additionally, lower levels of PROT‐a‐2454 (TRUB1) and PROT‐a‐332 (CA5A) were associated with AD (IVW: OR = 0.9520, 95% CI 0.9149–0.99070, p = 0.0156; IVW: OR = 0.9577, 95% CI 0.9197–0.9973, p = 0.0365). This evidence concerns the gene CA5A and Alzheimer disease.