As shown in Table 2, univariate Cox proportional hazards regression analysis showed that 17 variables were significantly associated with cardiac death: age, previous myocardial infarction, hospitalization for heart failure, hs-cTnT, BNP, eGFR, LAVI, LVEF, sPAP, MR, TR, RV-GLS, TAPSE/sPAP, RV-GLS/sPAP, VMT score, tafamidis use, and diuretics use. The gene discussed is NPPB; the disease is heart failure.