Recent studies have reported novel associations between the functional SNPs of the METTL14 gene and susceptibility to many human diseases, such as Wilms tumor (Zhuo et al., 2021), neuroblastoma (Zhuo et al., 2020), hepatoblastoma (Chen et al., 2022), acute lymphoblastic leukemia (Luo et al., 2021), and coronary heart disease (Sun et al., 2022). The gene discussed is METTL14; the disease is acute lymphoblastic leukemia.