LncRNA-miat/miR-22-3p/sirt1 axis activated the tumor suppressor pathway (p53/p21 and p16/pRb) and stimulated senescent cancer cells to secrete SASP, which contributed to inhibition of tumor cell proliferation, and resulted in the suppression of HCC tumorigenesis. Here, CDKN2A is linked to hepatocellular carcinoma.