LncRNA-miat/miR-22-3p/sirt1 axis activated the tumor suppressor pathway (p53/p21 and p16/pRb) and stimulated senescent cancer cells to secrete SASP, which contributed to inhibition of tumor cell proliferation, and resulted in the suppression of HCC tumorigenesis. The gene discussed is SIRT1; the disease is hepatocellular carcinoma.