HMGA2 and esophageal squamous cell carcinoma: These observations suggested that miR-125b-5p overexpression partially induced aging by downregulating HMGA2 in ESCC, with HMGA2 recognized as an aging-associated protein (Hammond and Sharpless, 2008; Keane and de Magalhaes, 2013; Yu et al., 2013; Tzatsos and Bardeesy, 2008).