In a recent research, endoplasmic reticulum (ER) stress was observed to the main cause of PD and ubiquitin ligase 3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase degradation 1 (HRD1) and its stabilizing molecule, the suppressor/enhancer lin‐12‐like (SEL1L) have a profound role in suppression ER stress Hence, luteolin suppress ER stress and activates HRD1 and SEL1L and might be a drug of choice to treat PD (Nishiguchi et al. 2024). This evidence concerns the gene SEL1L and Parkinson disease.