CW supplementation inhibits the high levels of inflammation induced by DSS, suppressing excessive inflammatory mediators (serum TNF‐α, IL‐1β, and IL‐6), downregulating the overexpressed mRNA levels of TNF‐α, IL‐1β, IL‐6, TLR4, and iNOS, while upregulating IL‐10, thereby alleviating colitis. The gene discussed is TLR4; the disease is colitis.