The involvement of necroptosis in intracellular bioenergetic regulation and inflammation through the contribution of RIPK3 to the necroptotic death of white adipocytes and the hepatocytes mitochondrial bioenergetics highlights this type of cell death as a marker of NAFLD (Islam, Afonso, and Rodrigues 2022; Leven et al. 2021). This evidence concerns the gene RIPK3 and metabolic dysfunction-associated steatotic liver disease.