Notably, during peak parasitemia and tissue complications under different treatments, there was an increase in IL-4 and IL-17 levels and a decrease in IFN-γ and TGF-β levels; elevated IL-4 levels and reduced levels of effective cytokines like IFN-γ potentially lead to diminished immune responses against intracellular parasites. This evidence concerns the gene TGFB1 and parasitic infectious disease.