There has been a significant downregulation in the expression level of ASPP1 in various forms of human cancer, including acute lymphoblastic leukemia, breast cancer, hepatocellular carcinoma bearing hepatitis B virus, clear cell renal cell carcinoma, and colorectal cancer (CRC) (10, 11, 15–17). This evidence concerns the gene PPP1R13B and hepatocellular carcinoma.