HCV: hepatocellular carcinoma; AFP: alpha-fetoprotein, FIB4: fibrosis 4, APRI: aspartate aminotransferase to platelet ratio index; ALT: alanine aminotransferase; AST: aspartate aminotransferase; VEGF: vascular endothelial growth factor. This evidence concerns the gene AFP and hepatocellular carcinoma.