This adipocytokine with multifaceted functions could suppress NADPH oxidase-induced ROS generation, RAGE gene expression, VEGF (vascular endothelial growth factor) expression and MMP-9 expression via interaction with laminin receptor, Moreover, decreased levels of PEDF expression in breast cancer tissue were linked to increased growth, aggressiveness, and metastasis (28). The gene discussed is VEGFA; the disease is breast carcinoma.