This adipocytokine with multifaceted functions could suppress NADPH oxidase-induced ROS generation, RAGE gene expression, VEGF (vascular endothelial growth factor) expression and MMP-9 expression via interaction with laminin receptor, Moreover, decreased levels of PEDF expression in breast cancer tissue were linked to increased growth, aggressiveness, and metastasis (28). This evidence concerns the gene FMO5 and breast carcinoma.