IFNG and neoplasm: Higher levels of IFN-γ were detected after stimulation with CMT64 and MC38 cells in the splenic T cells of mice treated with VVL-GL21 than in other groups, indicating that VVL-GL21 generates anti-tumor immunity against other types of tumors and that cross-antigens may exist in DT6606, CMT64, and MC38 cells (Figure 5B).