LASSO regression analysis (Figures 2A, B) and multifactorial COX regression analysis were used to conduct an in-depth study of DRGs and 12 genes were successfully identified as closely related to the prognosis of glioma patients genes that are closely related to the prognosis of glioma patients (BMP2, CDC25A, CDC25B, CDCA2, DUSP21, DUSP4, GNA12, HDDC2, LPIN3, LRRK2, MTMR11, PLPPR3) (Table 2). This evidence concerns the gene PLPPR3 and glioma.