However, it has also been pointed out that IL-6 can also play a role in inhibiting bone resorption when the level of RANKL in the local microenvironment is altered (81), so we believe that in the disease process intervened by MSCs, their effect on the function of B cells at different stages of periodontitis may also vary depending on the developmental stage of the B cells and the changes in the microenvironment (the function of bioactive factors), and the mechanism needs to be further explored. The gene discussed is TNFSF11; the disease is periodontitis.