The following factors have been associated with HNSCC risk in young patients: major histocompatibility complex class I-related chain A (MICA) A5.1 homozygous genotype (32), germline variants in FANCG, CDKN2A and TPP (33), drive genes ATXN1 and CDC42EP1 (34), rs6942067 GG genotype (35) in non-HPV and non-smokers, TP53 variation (36), HPV16 positive (37) and GSTM1 null genotype (38) were reported to be associated with HNSCC risk in young patients. This evidence concerns the gene CDKN2A and head and neck squamous cell carcinoma.