TP53 and head and neck squamous cell carcinoma: The following factors have been associated with HNSCC risk in young patients: major histocompatibility complex class I-related chain A (MICA) A5.1 homozygous genotype (32), germline variants in FANCG, CDKN2A and TPP (33), drive genes ATXN1 and CDC42EP1 (34), rs6942067 GG genotype (35) in non-HPV and non-smokers, TP53 variation (36), HPV16 positive (37) and GSTM1 null genotype (38) were reported to be associated with HNSCC risk in young patients.