ALDH1A1 and malignant colon neoplasm: In addition, NEAT1 increased the level of histone acetylation, and the heightened histone enrichment at the ALDH1 and c-Myc promoters led to the upregulation of ALDH1 and c-Myc expression, thereby impacting 5-Fu resistance in colon cancer cells through modulation of cancer cell stemness (53).