NCAPD3 upregulates c-Myc levels and interacts with c-Myc, recruiting it to downstream glycolytic regulators such as GLUT1, HK2, ENO1, PKM2, and LDHA gene promoters, ultimately enhancing cellular aerobic glycolysis, promoting the Warburg effect, and driving colorectal cancer development and progression (94). This evidence concerns the gene HK2 and colorectal cancer.