Some researchers verified the role of CAFs-EVs containing SNHG3 in vivo by establishing a xenograft tumor model and found that SNHG3 promotes CRC cell proliferation by increasing HuR expression through the sponge miR-34b-5p and ultimately enhancing HOXC6 transcription (28, 29). This evidence concerns the gene HOXC6 and colorectal carcinoma.