In addition, NEAT1 increased the level of histone acetylation, and the heightened histone enrichment at the ALDH1 and c-Myc promoters led to the upregulation of ALDH1 and c-Myc expression, thereby impacting 5-Fu resistance in colon cancer cells through modulation of cancer cell stemness (53). The gene discussed is NEAT1; the disease is malignant colon neoplasm.