The imbalance of the ADAMTS13-VWF axis due to chronic hyperglycemia may lead to thrombotic vascular disease in diabetic patients, while intrarenal thrombosis aggravates diabetic nephropathy (Rurali et al., 2013; Taniguchi et al., 2010; Dhanesha et al., 2017). The gene discussed is VWF; the disease is Venous thrombosis.