Depending on the pathogenesis of DN, some potential drugs corresponding to DN have also been shown to have therapeutic effects on DN in recent years, such as empagliflozin, where Linagliptin -mediated inhibition of dipeptidyl peptidase 4 (DPP4) hinders EMT to ameliorate renal fibrosis in DN (Kanasaki et al., 2014; Li et al., 2020b). This evidence concerns the gene DPP4 and renal fibrosis.