In addition, our study found that BSTZC inhibited the mRNA levels of PI3KCA, AKT, TNF, PTGS2, and TNF, suggesting that BSTZC may alleviate HLP by inhibiting the PI3K/AKT signaling pathway, further validating the results of the network analysis. This evidence concerns the gene AKT1 and hyperkeratosis lenticularis perstans.