The alcohol extract of Tiekuaizi can reduce the level of serum TNF-α, inhibit the expression of inflammatory factors, play an anti-inflammatory effect, and have a certain protective effect on myocardial ischemia. The indexes of CK-MM, and CK-MB in high, middle and low dose groups of alcohol extract of Tiekuaizi were lower than those in model group. The gene discussed is TNF; the disease is myocardial ischemia.