NFKB1 and chronic obstructive pulmonary disease: Sodium tanshinone IIA sulfonate is effective in treating COPD, which can alleviate inflammatory response and prevent acute exacerbation of COPD by inhibiting the activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) (Li D. et al., 2020), and improve airway dehydration symptoms by stimulating Cl-secretion in mouse tracheal epithelium (Chen P. X. et al., 2017).