Lin et al. discovered a regulatory mechanism between NEAT1 and mitophagy mediated by PINK1, and the increase of NEAT1, PINK1, and Parkin in the lung tissue of rats with COPD induced by CS or PM2.5,resulted in mitochondrial swelling, subsequently inducing mitophagy, and ultimately triggering the formation of autophagosomes. This evidence concerns the gene NEAT1 and chronic obstructive pulmonary disease.