Studies have shown that glycocholic acid may activate the FXR receptor and reduce the number of Treg cells in the tumor microenvironment by inhibiting the expression of the PI3K/AKT signaling pathway in Treg cells, thereby promoting tumor cell apoptosis and inhibiting tumor growth (Li et al., 2018; Ren et al., 2019; Xiang et al., 2019). Here, AKT1 is linked to neoplasm.