AHR and colonic neoplasm: AHR-deficient mice are prone to develop intestinal inflammation, which in turn progresses into colon cancer; An I3C-rich diet normalizes intestinal stem cell proliferation, expedites their differentiation into intestinal epithelial cells and goblet cells, augments the expression of tight junction proteins, increases intestinal barrier integrity, and reduces the incidences of colitis and colon cancer (Hao et al., 2012; Jiang et al., 2013; Hubbard et al., 2015).