Researchers found that proinflammatory factors such as interleukin-1β (IL-1β), interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor-α (TNF-α) can be used as important inflammatory biomarkers to detect PD from the serum and cerebrospinal fluid (CSF) of patients with PD (Liu et al., 2022). This evidence concerns the gene TNF and Parkinson disease.