Papalazarou et al. revealed mechanosensitive insights into the role of CKB-mediated pCr-CK metabolism in PDAC by showing that CKB plays a critical role following YAP-mediated transcriptional regulation to drive phosphocreatine synthesis, cancer cell invasion, chemotaxis and metastasis (Papalazarou et al. 2020). The gene discussed is CKB; the disease is cancer.