The Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed that multiple common pathways in GC, such as neuroactive ligand–receptor interaction, WNT signaling pathway, proteoglycans in cancer, and cell adhesion molecules, were top enriched, which provides biological explanations on the mechanism of DCAF4L2 mutation exacerbating the disease (Figure S5J). The gene discussed is DCAF4L2; the disease is cancer.