Ten potential HNSCC driver targets were then identified via AlloDriver: ERAP1 (p.K528R), TP53 (p.S241C, pC176F), KIF5B (p.Q58P), HAAO (p.T42S), SRR (p.G239S), TF (p.H268P), PGD (p.H435Q), GUSB (p.H351Q), and CBS (p.D238E), most of which have not been previously reported in HNSCC (Figure 1D). Here, GUSB is linked to head and neck squamous cell carcinoma.