By the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, the upregulated DEGs were enriched in focal adhesion, extracellular matrix (ECM)‐receptor interactions, Rap1 signaling pathways, proteoglycans in cancer, the PI3K‐Akt signaling pathway, and Ras signaling pathway in GUSB‐WT and GUSB‐H351Q groups as compared to the Vector group (Figure S6E,F). The gene discussed is AKT1; the disease is cancer.