Ten potential HNSCC driver targets were then identified via AlloDriver: ERAP1 (p.K528R), TP53 (p.S241C, pC176F), KIF5B (p.Q58P), HAAO (p.T42S), SRR (p.G239S), TF (p.H268P), PGD (p.H435Q), GUSB (p.H351Q), and CBS (p.D238E), most of which have not been previously reported in HNSCC (Figure 1D). The gene discussed is TP53; the disease is head and neck squamous cell carcinoma.